gbanyan
a228a56984
gene_universe contains 1,539 gene_symbols mapping to multiple Ensembl IDs (3,033 excess). Non-canonical IDs lack data in some evidence tables, causing weighted_sum/available_weight to inflate their composite scores. Fix: after scoring SQL, keep one row per gene_symbol with the most evidence_count (tiebreak by composite_score DESC). 22,604 → 19,555 genes. Results: HIGH 82→4, all top 20 now have 5-6 layers with expression data. Validation PASSED (CDH23 98.3rd percentile, median known gene 83.3%). Co-Authored-By: Claude Opus 4.6 <noreply@anthropic.com>
34 lines
658 B
YAML
34 lines
658 B
YAML
generated_at: '2026-02-16T01:59:18.621053+00:00'
|
|
output_files:
|
|
- candidates.tsv
|
|
- candidates.parquet
|
|
statistics:
|
|
total_candidates: 18243
|
|
high_count: 4
|
|
medium_count: 8051
|
|
low_count: 10188
|
|
column_count: 22
|
|
column_names:
|
|
- gene_id
|
|
- gene_symbol
|
|
- gnomad_score
|
|
- expression_score
|
|
- annotation_score
|
|
- localization_score
|
|
- animal_model_score
|
|
- literature_score
|
|
- evidence_count
|
|
- available_weight
|
|
- weighted_sum
|
|
- composite_score
|
|
- quality_flag
|
|
- gnomad_contribution
|
|
- expression_contribution
|
|
- annotation_contribution
|
|
- localization_contribution
|
|
- animal_model_contribution
|
|
- literature_contribution
|
|
- confidence_tier
|
|
- supporting_layers
|
|
- evidence_gaps
|