v5 of top20 report adds key biological insights: dynein system dominance (#1 + #2), Na+/K+ pump convergence (3 subunits in top 20), ARL3 as best novel ciliopathy candidate (52% cilia literature), MAPRE3 as most under-studied high-scoring gene (81 papers). Co-Authored-By: Claude Opus 4.6 <noreply@anthropic.com>