usher-exploring

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gbanyan adbb74b965 feat(03-01): implement annotation evidence fetch and transform modules

- Create AnnotationRecord model with GO counts, UniProt scores, tier classification
- Implement fetch_go_annotations using mygene.info batch queries
- Implement fetch_uniprot_scores using UniProt REST API
- Add classify_annotation_tier with 3-tier system (well/partial/poor)
- Add normalize_annotation_score with weighted composite (GO 50%, UniProt 30%, Pathway 20%)
- Implement process_annotation_evidence end-to-end pipeline
- Follow NULL preservation pattern from gnomAD (unknown != zero)
- Use lazy polars evaluation where applicable

2026-02-11 18:58:45 +08:00

.planning

docs(03): create phase plan

2026-02-11 18:46:28 +08:00

config

feat(01-01): create Python package scaffold with config system

2026-02-11 16:24:35 +08:00

src/usher_pipeline

feat(03-01): implement annotation evidence fetch and transform modules

2026-02-11 18:58:45 +08:00

tests

test(02-02): add comprehensive gnomAD integration tests