gbanyan 174c4af02d feat(02-01): add gnomAD transform pipeline and comprehensive tests ...

- Implement filter_by_coverage with quality_flag categorization (measured/incomplete_coverage/no_data)
- Add normalize_scores with LOEUF inversion (lower LOEUF = higher score)
- NULL preservation throughout pipeline (unknown != zero constraint)
- process_gnomad_constraint end-to-end pipeline function
- 15 comprehensive unit tests covering edge cases:
  - NULL handling and preservation
  - Coverage filtering without dropping genes
  - Normalization bounds and inversion
  - Mixed type handling for robust parsing
- Fix column mapping to handle gnomAD v4.x loeuf/loeuf_upper duplication
- All existing tests continue to pass

2026-02-11 18:14:41 +08:00

13 KiB

Raw Blame History

View Raw