gbanyan
174c4af02d
- Implement filter_by_coverage with quality_flag categorization (measured/incomplete_coverage/no_data) - Add normalize_scores with LOEUF inversion (lower LOEUF = higher score) - NULL preservation throughout pipeline (unknown != zero constraint) - process_gnomad_constraint end-to-end pipeline function - 15 comprehensive unit tests covering edge cases: - NULL handling and preservation - Coverage filtering without dropping genes - Normalization bounds and inversion - Mixed type handling for robust parsing - Fix column mapping to handle gnomAD v4.x loeuf/loeuf_upper duplication - All existing tests continue to pass