usher-exploring

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gbanyan 0cd2f7c9dd feat(04-01): implement known gene compilation and ScoringWeights validation

- Create scoring module with OMIM_USHER_GENES (10 genes) and SYSCILIA_SCGS_V2_CORE (28 genes)
- Implement compile_known_genes() returning DataFrame with gene_symbol, source, confidence
- Add load_known_genes_to_duckdb() to persist known genes table
- Add ScoringWeights.validate_sum() method enforcing weight sum constraint (1.0 ± 1e-6)

2026-02-11 20:41:31 +08:00

.planning

docs(04): create phase plan for scoring and integration

2026-02-11 20:31:55 +08:00

config

feat(01-01): create Python package scaffold with config system

2026-02-11 16:24:35 +08:00

src/usher_pipeline

feat(04-01): implement known gene compilation and ScoringWeights validation

2026-02-11 20:41:31 +08:00

tests

docs(03-04): complete subcellular localization evidence layer