2 Commits

Author	SHA1	Message	Date
gbanyan	174c4af02d	feat(02-01): add gnomAD transform pipeline and comprehensive tests ... - Implement filter_by_coverage with quality_flag categorization (measured/incomplete_coverage/no_data) - Add normalize_scores with LOEUF inversion (lower LOEUF = higher score) - NULL preservation throughout pipeline (unknown != zero constraint) - process_gnomad_constraint end-to-end pipeline function - 15 comprehensive unit tests covering edge cases: - NULL handling and preservation - Coverage filtering without dropping genes - Normalization bounds and inversion - Mixed type handling for robust parsing - Fix column mapping to handle gnomAD v4.x loeuf/loeuf_upper duplication - All existing tests continue to pass	2026-02-11 18:14:41 +08:00
gbanyan	a88b0eea60	feat(02-01): add gnomAD constraint data models and download module ... - Create evidence layer package structure - Define ConstraintRecord Pydantic model with NULL preservation - Implement streaming download with httpx and tenacity retry - Add lazy TSV parser with column name variant handling - Add httpx and structlog dependencies	2026-02-11 18:11:49 +08:00