fix: rescue gnomAD genes with non-Ensembl IDs via gene_symbol fallback
gnomAD v4.1 gene_id column is mixed: ~101K Ensembl IDs + ~111K NCBI numeric. Now falls back to gene_symbol → gene_universe lookup for non-ENSG entries. Coverage: 78.5% → 90.3% (17,875 → 20,555 genes with gnomAD scores). Sufficient evidence (≥4 layers): 19,946 → 20,683 genes. Validation median percentile: 79.9% → 81.1%. Co-Authored-By: Claude Opus 4.6 <noreply@anthropic.com>
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@@ -1,6 +1,6 @@
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{
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"run_id": "e7486ff1-f9be-403b-a68d-115fc845f4a1",
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"timestamp": "2026-02-15T21:13:12.288563+00:00",
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"run_id": "093b405b-5a20-4f35-b5b8-04f02451789d",
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"timestamp": "2026-02-15T21:49:14.940206+00:00",
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"pipeline_version": "0.1.0",
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"parameters": {
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"gnomad": 0.2,
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@@ -49,9 +49,9 @@
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],
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"validation_metrics": {},
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"tier_statistics": {
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"total": 21103,
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"high": 18,
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"medium": 9577,
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"low": 11508
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"total": 21177,
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"high": 82,
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"medium": 9626,
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"low": 11469
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}
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}
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