fix: rescue gnomAD genes with non-Ensembl IDs via gene_symbol fallback

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gnomAD v4.1 gene_id column is mixed: ~101K Ensembl IDs + ~111K NCBI numeric.
Now falls back to gene_symbol → gene_universe lookup for non-ENSG entries.

Coverage: 78.5% → 90.3% (17,875 → 20,555 genes with gnomAD scores).
Sufficient evidence (≥4 layers): 19,946 → 20,683 genes.
Validation median percentile: 79.9% → 81.1%.

Co-Authored-By: Claude Opus 4.6 <noreply@anthropic.com>

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This commit is contained in:

gbanyan

2026-02-16 05:49:27 +08:00

parent 13bba55ac7

commit e2a3dc2bc8

9 changed files with 6546 additions and 6450 deletions

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