fix: deduplicate gene_symbol in scoring to prevent non-canonical ID inflation
gene_universe contains 1,539 gene_symbols mapping to multiple Ensembl IDs (3,033 excess). Non-canonical IDs lack data in some evidence tables, causing weighted_sum/available_weight to inflate their composite scores. Fix: after scoring SQL, keep one row per gene_symbol with the most evidence_count (tiebreak by composite_score DESC). 22,604 → 19,555 genes. Results: HIGH 82→4, all top 20 now have 5-6 layers with expression data. Validation PASSED (CDH23 98.3rd percentile, median known gene 83.3%). Co-Authored-By: Claude Opus 4.6 <noreply@anthropic.com>
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@@ -1,6 +1,6 @@
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{
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"run_id": "093b405b-5a20-4f35-b5b8-04f02451789d",
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"timestamp": "2026-02-15T21:49:14.940206+00:00",
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"run_id": "f5587e39-163b-418c-8ac2-593b47323f34",
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"timestamp": "2026-02-16T01:59:18.969516+00:00",
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"pipeline_version": "0.1.0",
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"parameters": {
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"gnomad": 0.2,
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@@ -49,9 +49,9 @@
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],
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"validation_metrics": {},
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"tier_statistics": {
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"total": 21177,
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"high": 82,
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"medium": 9626,
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"low": 11469
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"total": 18243,
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"high": 4,
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"medium": 8051,
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"low": 10188
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}
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}
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