#CHROM	POS	REF	ALT	SYMBOL	Consequence	Protein_position	PolyPhen	SIFT	CLIN_SIG	AF	gnomAD_AF	SpliceAI	CADD_PHRED
1	123456	A	T	GJB2	missense_variant	p.Val37Ile	benign	tolerated	Benign	0.012	0.012	0.02	5.1
2	234567	G	C	OTOF	stop_gained	p.*	probably_damaging	deleterious	Uncertain_significance	0.0001	0.0001	0.6	28.5