# ACMG evidence thresholds (example, adjust per lab policy)
ba1_af: 0.05   # Stand-alone benign if AF >= this
bs1_af: 0.01   # Strong benign if AF >= this (and not meeting BA1)
pm2_af: 0.0005 # Moderate pathogenic if AF <= this
bp7_splice_ai_max: 0.1 # Supporting benign if synonymous and predicted low splice impact

# Genes considered loss-of-function sensitive for PVS1 auto-tagging
lof_genes:
  - BRCA1
  - BRCA2
  - TTN
  - CFTR