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configs/acmg_config.example.yaml

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+# ACMG evidence thresholds (example, adjust per lab policy)
+ba1_af: 0.05   # Stand-alone benign if AF >= this
+bs1_af: 0.01   # Strong benign if AF >= this (and not meeting BA1)
+pm2_af: 0.0005 # Moderate pathogenic if AF <= this
+bp7_splice_ai_max: 0.1 # Supporting benign if synonymous and predicted low splice impact
+
+# Genes considered loss-of-function sensitive for PVS1 auto-tagging
+lof_genes:
+  - BRCA1
+  - BRCA2
+  - TTN
+  - CFTR